irritation

noun
  1. The state of feeling annoyed, impatient, or slightly angry. noun
    She felt a sense of irritation when the meeting was delayed yet again.
    His constant humming was a source of irritation to everyone in the office.
  2. A condition of soreness or inflammation, often of the skin, caused by an external agent or stimulus. noun
    The lotion helped to soothe the irritation caused by the sunburn.
    Wearing wool can sometimes cause irritation to sensitive skin.