debilitation

noun
  1. The process or state of weakening or reducing the strength or effectiveness of something or someone. noun
    The debilitation of the patient's immune system made it difficult for them to recover from the illness.
    Years of neglect led to the debilitation of the once-thriving industrial area.
  2. A condition of being physically or mentally weakened. noun
    The debilitation caused by the disease left him unable to perform daily tasks without assistance.
    Chronic stress can lead to the debilitation of mental health over time.